Speak®+d contents help in
- Supporting cognitive function
- Improving in speech ability
- behavioral improvements
- Providing antioxidant support
Omega-3
The central nervous system is rich in highly unsaturated fatty acids, which cannot be synthesized by the human body but must be supplied by nutrition.
Highly unsaturated fatty acids are essential for normal brain development and function. Dietary consumption of omega-3 fatty acids EPA (eicosapentaenoic) acid and DHA (docosahexaenoic acid) , commonly found in fish and fish oil, may modify the risk for certain neuropsychiatric disorders. There also is increasing evidence that fatty acid deficiencies or imbalances may contribute to childhood neurodevelopmental disorders, including Autism spectrum disorder, attention-deficit/hyperactivity disorder, dyslexia and dyspraxia.
Blood biochemical and other studies has been accumulating supporting evidences that children with neurodevelopment disorders like Autism Spectrum disorder share common deficiency in essential fatty acids. Deficiency might be due to different reasons including lesser intake of highly unsaturated fatty acids metabolic disorder and to oxidative stress in Autism and other conditions that cause lipid perodixation, that’s why it’s important to augment omega-3 supplementation with antioxidants like vitamin E.
Recent researches improved the understanding of the different roles of omega-3 ingredients. Where DHA the more famous ingredient which plays a role in brain development and most of marketed omega-3 supplements contains high percentage of DHA, it’s recently found the EPA play an important role in neurodevelopment conditions like in Autism, where EPA plays an important role in neurotransmission in these conditions, accordingly ratio of EPA to DHA in speak®+d made specifically to meet nutritional requirements of these conditions.
Omega-3 deficiency is associated with behavioral, social and learning problems as well as with some aspects of general health. Multiple researches proved the positive impact of omega-3 supplementation in Autism with significant improvement in hyperactivity, inappropriate speech, irritability and social skills. Accordingly, Omega-3 can be considered a safe and tolerable intervention in autism spectrum disorder, attention-deficit/hyperactivity disorder, dyslexia and dyspraxia.
Vitamin D
The vitamin D system is best known for its impact on bone mineral density, however optimal concentrations of vitamin D are also required for brain function and development
Vitamin D is a gene activator that creates the enzyme converting tryptophan into serotonin in the brain that functions as neurotransmitter. It plays an essential role in myelination, which is important for connectivity in the brain. Also, vitamin D play role via act as calcium signaling, neurotrophic and neuroprotective.
Because of vitamin D role in affecting brain development and function, It may play an important role in etiology of Autism Spectrum Disorders. That was studied by measuring vitamin D level in in patients with ASD in different ages compared with the control group. The finding of 5 studies in different parts of the world indicate lower vitamin D level in patients with ASD compared with the control group.
studies have shown that decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk of ASD. A studied large population-based sample concluded that gestational vitamin D deficiency was associated with autism-related traits. Another study also concluded gestational vitamin D deficiency is associated with impairment on a range of cognitive outcomes related to language, motor development and general intelligence.
In a clinical study with autism, receiving vitamin D supplement for three months. The parents of the children in the group receiving vitamin D rated significant improvement in irritability, hyperactivity, social withdrawal, stereotypic behavior and inappropriate speech. These researchers using multiple behavioral checklists reported significant improvements in social cognition and social awareness and significant decrease in repetitive hand movements, creation of noises, jumping, and restricted interests.
Vitamin E
Available naturally in nuts, recent developments confirmed that vitamin E plays essential role in the human nervous system.
the field of clinical nutrition have confirmed that vitamin E plays essential role in maintaining the structure and function of the human nervous system. The most widely accepted physiological function of vitamin E is its role asa scavenger of free radicals, preventing oxidant injury to cell membrane polyunsaturated fatty acids.
Recently, it has been proposed that vitamin E deficiency resulted independently or secondary to malabsorption diseases maybe responsible for the varied psychomotor abnormalities sand may contribute to the high incidence of behavioral and personality disorders.
On the other hand, autistic children are more vulnerability to oxidative stress compared to their developmentally normal non-autistic siblings. A comparison between autistic children and their normal siblings lead to proving that Autistic children have significantly higher lipid peroxidation and decreased level of body antioxidants like glutathione, transferrin and ceruloplasmin compared to their normal siblings. A striking correlation was observed between reduced levels of these proteins and loss of previously acquired language skills in children with autism.
Vitamin E, at high dosage, showed significant in the reduction of oxidative stress through its protective role in the nervous system by fighting against lipid peroxidation. Accordingly, it is believed that vitamin E supplementation improve effectiveness of supplemented omega-3
Vitamin K
Vitamin K found natural in green vegetables, it plays and important role in the nervous system
Vitamin K is essential for the synthesis of sphingolipids. sphingolipids are present in high concentrations in brain cell membranes, known to possess important cell signaling functions in addition to their structural role.
Also, vitamin K–dependent proteins that are now known to play key roles in the central and peripheral nervous systems actively involved in cell survival, and cell growth of neurons. These data confirm the relevance of vitamin K in the nervous system and cognition, however limited number of studies have provided evidence of a relationship between vitamin K status and behavior.
vitamin K–dependent proteins that are now known to play key roles in the central and peripheral nervous systems actively involved in cell survival, and cell growth of neurons. These data confirm the relevance of vitamin K in the nervous system and cognition, however limited number of studies have provided evidence of a relationship between vitamin K status and behavior.
Oxidative mechanisms of injury are important in many neurological disorders, Children with autism and other neurological condition found to have high oxidative stress and reduced level of natural body antioxidants like Glutathione. Although vitamin K is not a classical antioxidant, it is reported that vitamin K1 and K2 potently inhibit glutathione depletion-mediated oxidative cell death
The protective and potent efficacy of this naturally occurring vitamin, with no established clinical side effects, suggests a potential therapeutic application in preventing oxidative damage.